Functioning of the ADAMTS-13/vWF axis and its clinical significance

Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both health and disease. ADAMTS-13 (a disintegrin metalloproteinase with thrombospondin type 1 motif, member 13) von Willebrand factor (vWF) are components of the system, which physiological interaction holds an important place maintaining homeostasis. is a mainly acting release vWF fragments into blood plasma, as well regulating its activity by cleaving ultra-large multimers (UL-vWF) smaller less active forms. The study such factors great clinical importance, since decrease increase level can be predictors microcirculatory disorders that play role developing multiple organ failure. However, very few fully contradictory studies devoted aspects ADAMTS-13/vWF axis mother–fetus system available, therefore requiring further investigated.